The level of IL-10 in patients after myocardial infarction correlates with the activity of metalloproteinases, which are a group of proteins that digest elements of the extracellular stroma and are a marker of atherosclerotic plaque instability; they contribute to the progression of coronary artery disease and plaque rupture [38,39]. The gene discussed is IL10; the disease is myocardial infarction.