IDO2 and acute myeloid leukemia: With human indoleamine 2,3-dioxygenase upregulated in key human tissues (i.e., small intestine and lung), and a number of cancers (i.e., acute myeloid leukemia, ovarian, and colorectal carcinoma), knowledge that aplysinopsins are substrates, and yield potent Michael acceptors, could inform future development of this pharmacophore.