In rats, the administration of dried A. maxima (62.5, 125, or 250 mg/kg) also reduced weight gain and the elevated WAT index induced by an HF diet, and it attenuated the changes related to metabolic alterations, including serum adiponectin, leptin, tumor necrosis factor α (TNF-α), glucose, insulin, and the lipid profile. The gene discussed is TNF; the disease is hydrops fetalis.