VWF and metastatic malignant neoplasm: While ADAM28 acts as a semi-functional homologue of ADAMTS-13 in cleaving circulating VWF, it is interesting to note that while ADAMTS-13 levels have been shown to decrease in a range of metastatic cancer including breast, ADAM28 expression is correlated with advanced disseminated disease [30, 72, 87, 88].