CNR2 and colitis: Cannabinoids were shown to ameliorate colitis in various murine models of colitis, with an anti-inflammatory effect mediated thorough activation of the cannabinoid receptors CB1 and CB2, inhibition of the endocannabinoid degrading enzymes Monoacylglycerol lipase(MAGL) and fatty acid amid hydrolase (FAAH), and activation of the G protein-coupled receptor 55 (GPR55) and Transient receptor potential vanilloid 1 (TRPV1) receptors [25, 26].