With the increasing interest in ECM and MMPs role in tissue remodelling and disease development, the current study explored the role of MMP-9 in the pathogenesis of atherosclerosis through investigating the effect of induction of atherosclerosis on MMP-9 gene expression in aortic strips and its correlation to atherosclerosis developing factors (dyslipidaemia and inflammatory markers). This evidence concerns the gene MMP9 and atherosclerosis.