Mutations in EYS are known to cause recessive retinitis pigmentosa [34,35], though there was no obvious link to T2D other than a suggestive association with T2D in Europeans (rs10498828, ~670kb away, P = 9x10-6), and a genome-wide association with BMI in a Japanese population (rs148546399, ~1.5Mb away, P = 1x10-9) [36,37]. Here, EYS is linked to type 2 diabetes mellitus.