Our results indicate PA-associated DNAm signatures at targeted genomic regions are associated with 12 genes, of which 7 are potentially novel to food allergy (brain-derived neurotrophic factor [BDNF], IL17F, CXCL12, CCR7, runt-related transcription factor 1 [RUNX1], CD3ε, and SERPINE1); 3 are associated with Th1/Th2 responses (IL4, IL12B, and IL2) and 2 are associated with innate immune responses (IL1B and IL6). The gene discussed is IL2; the disease is food allergy.