MJD is a rare and progressive autosomal dominant neurodegenerativedisorder and has features similar to those of other polyglutaminediseases such as HD.89 An in vivo studyillustrated that NPY overexpression alleviated motor coordinationand balance disabilities, prevented an increase of the mutant ataxin-3induced in microglial immune reactivity, up-regulated BDNF levels,and reduced the proinflammatory cytokine IL-6 mRNA levels in an MJDmouse.90 The increasing levels of BDNFand reduction of neuroinflammation demonstrated the beneficial effectsof NPY on MJD. The gene discussed is NPY; the disease is Huntington disease.