Thus, the involvement of the orexinergic system in thepathophysiology sleep disturbances in AD patients was extensivelyinvestigated.113 In addition, it was shownthat orexin inhibits Aβ uptake and induces degradation in microglialcells.107 Orexin has also exhibited neuroprotectiveactivity in mice models.114. This evidence concerns the gene HCRT and Alzheimer disease.