Somatostatin has been detectedin several brain regions playing a role in learning processes, e.g.,the amygdala, hippocampus, striatum, and cerebral cortex.119 Somatostatinergic systems in the brain arecrucial in several physiological and pathological neuronal functionsand in neurodegenerative diseases.120 Moreover,it was shown that somatostatin is involved in cognitive and emotionalprocesses by modulating the function of the respective brain areas.121 Finally, lower levels of somatostatin in thecerebral cortex and cerebrospinal fluid are typical hallmarks of ADpatients.122. The gene discussed is SST; the disease is neurodegenerative disease.