The typical immunoprofile of usual-type HPV-associated adenocarcinoma is negative staining for estrogen receptor (ER), progesterone receptor (PR), vimentin, MUC6, HNF1beta, Napsin A, GATA3, androgen receptor (AR), and human epidermal growth factor receptor 2 (HER2); p53 is usually wild-type. Here, ERBB2 is linked to adenocarcinoma.