Serous carcinoma of the cervix is no longer accepted as a primary tumor type, as all such tumors are p16-negative and HPV-positive, and almost always p53 wild-type, in contrast to true serous carcinomas such tumors are regarded as HPV-associated endocervical adenocarcinomas rather than serous carcinomas. This evidence concerns the gene CDKN2A and serous adenocarcinoma.