There were no significant differences between the 2 groups in sex, race, smoking status, simplified comorbidity scores, histology, driver alteration status, number of metastatic sites, or line of therapy; however, patients with ECOG PS scores of at least 2 had numerically higher absolute neutrophil counts as well as higher rates of obesity and PD-L1 TPS of at least 50%. The gene discussed is CD274; the disease is obesity due to melanocortin 4 receptor deficiency.