KLK3 and cancer: For clinically insignificant cancers, PSA testing (≥3 ng/mL) detected 6 cases, MRI score of 3 to 5 detected 7 cases, MRI score of 4 to 5 detected 5 cases, ultrasonography score of 3 to 5 detected 13 cases, and ultrasonography score of 4 to 5 detected 7 cases (eFigures 3-8 and eTable 1 in the Supplement).