B3GAT2 and inflammatory bowel disease: This circumstance is well illustrated by the reduced levels of mRNA of genes in the glucuronidation pathway, which is important because the intestinal expression of some UDP-glucuronosyltransferases has been reported as critical for the detoxification of certain chemotherapies such as irinotecan32 and thus macrophages could play an important role in pharmacokinetics, which may influence treatment responses in IBD.