Previous research noted an accumulation of Th1 and ILC in the colon of patients with PSC-UC,11 and other studies have implicated Th17 responses in the pathogenesis of PSC-IBD.10, 19, 20 In this study, we aimed to evaluate the role of immune-epithelial interactions in the pathogenesis of PSC-UC and the increased risk of CRC using patient-derived EpOCs. Here, CCL27 is linked to inflammatory bowel disease.