FBN1 and Myocardial fibrosis: miR-29b upregulation because of TGF/Smad3 inactivation downregulated profibrotic genes, such as ECM genes elastin (159), fibrillin 1 (Fbn1), collagen type I, 1 and 2 (Col11, Col12), and collagen type III, 1 (Col31) (160) and enhanced cardioprotective impacts of carvedilol vs. myocardial fibrosis triggered by AMI (79, 125).