Based on existing evidence, miR-133a overexpression has prevented myocardial fibrotic event in both AngII-related hypertension and diabetes, even though the effector proteins were different in diabetes (fibronectin and COL4A1) and AngII-related hypertension (COL1A1) (21, 121, 162). This evidence concerns the gene COL1A1 and hypertensive disorder.