Moreover, in C57BL/6J mice with induced DN, local treatment with lentivirus particles encoding a miR-802 sponge by ultrasound-microbubbles effectively suppressed the mRNA levels of inflammatory factors, including TNF-α, IL-6, iNOS, and MCP-1, thus blocking macrophage accumulation and reducing the inflammatory response in diabetic kidneys (Sun D. et al., 2019). The gene discussed is CCL2; the disease is liver dysplastic nodule.