IL18 and liver dysplastic nodule: Blocking Btk either chemically (LFM-A13 inhibitor) or by overexpression of miR-346 mimics inhibits the secretion of IL-18, which provides evidence that targeting miR-346 could regulate IL-18 expression as a promising immunomodulating strategy in DN (Alsaleh et al., 2009; Zhang et al., 2015).