TNF-α binds to the TNFR1 (p55) receptor, resulting in the production/expression of diverse effectors include adhesion molecules, major histocompatibility complex (MHC) proteins, cytokines, growth factors, transcription factors (TFs) and acute phase proteins, leading to direct renal cell cytotoxicity, apoptosis, intra-glomerular haemodynamic alterations and kidney inflammation, which play a prominent role in DN pathogenesis (Pavkov et al., 2015). The gene discussed is TNF; the disease is liver dysplastic nodule.