Then, activated NF-κB increases the accumulation of IL-1β, ICAM-1, and TNF-α and induces glomerular macrophage secretion and CD4+ Th17 T cell infiltration in glomerular and tubulointerstitial cells, eventually enhancing proximal tubule and tubulointerstitial inflammation and DN progression (Lan, 2011) (Figure 8). This evidence concerns the gene IL1B and liver dysplastic nodule.