Moreover, the potent natural antioxidant and anti-inflammatory resveratrol is known to act on Sirt1, with positive antiaging effects on both brain (Sarubbo et al., 2017; Gomes et al., 2018) and vasculature (Kida and Goligorsky, 2016), also protecting vascular endothelial cells from atherosclerosis (a chronic inflammatory process associated with endothelial dysfunction and oxidative stress) (Wu et al., 2020). The gene discussed is SIRT1; the disease is endothelial dysfunction.