Five of these miRNAs (miR-34c, miR-29b, miR-29c, miR-141, and miR-181a) were previously linked to OC degeneration during age-related hearing loss (ARHL, also known as presbycusis) (Zhang et al., 2013) and share Sirt1 as a common silencing gene target, which they are known to inhibit transcriptionally and/or post-transcriptionally in both humans and mice (Table 1). Here, SIRT1 is linked to presbycusis.