VEGFA and age-related macular degeneration: Finally, an off-label drug for AMD treatment, Bevacizumab (Genentech), is a full-length humanized monoclonal antibody against VEGF, with a longer systemic half-life than other anti-VEGF agents (e.g., about 21 days for bevacizumab, vs. 2.2 h for ranibmizumab) (Ferrara et al., 2004; Wang et al., 2004; Yang and Wang, 2004; Heier et al., 2012; Bakall et al., 2013; Busbee et al., 2013; Rofagha et al., 2013; Ferrone et al., 2014; Grewal et al., 2014; Schmidt-Erfurth et al., 2014; Bhisitkul et al., 2015; Avery et al., 2017).