VEGFA and wet macular degeneration: Finally, tert-butylhydroperoxide (tBH) mediated oxidative stress reduces survival of choroidal endothelial cells in vitro, and RPE cells exposed to tBH-mediated oxidative stress secrete increasing amounts of bFGF but not vascular endothelial growth factor (VEGF) in culture and support proliferation of choroidal endothelial cells, suggesting a mechanism leading to neovascularization as seen in wet AMD (Eichler et al., 2008).