In conclusion, GFAP astrocytopathy, a relatively new autoimmune disorder of the CNS, should be considered in children clinically diagnosed with meningoencephalitis (whether or not it presents with myelitis) and have MRIs that reveal meninges or spine enhancement, T2-hyperintense lesions, or a pattern of linear perivascular gadolinium enhancement. The gene discussed is GFAP; the disease is myelitis.