Our results of RNA pull-down assay, luciferase reporter assay, RT-qPCR and Western blot analysis suggested that the expression of FOXQ1 was inhibited by miR-4319 mimics or depletion of LINC00667, implicating that LINC00667 might upregulate FOXQ1 by inhibiting miR-4319.Moreover, our xenograft mouse model validated the role of LINC0066 in promoting NPC cell growth in vivo, and the relationship of LINC0066, miR-4319 and FOXQ1.Our results suggest thatLINC00667 might serve as an oncogene in the development of NPC via targeting miR-4319/FOXQ1 axis. The gene discussed is FOXQ1; the disease is nasopharyngeal carcinoma.