HSP90AA1 and cancer: In fact, many HSP90 client proteins are cancer-promoting molecules playing key roles in cancer development and progression, such as the Focal Adhesion Kinase (FAK) involved in cellular adhesion, the Epidermal Growth Factor Receptor (EGFR) and Protein Kinase B (AKT) that are involved in cell growth and proliferation, the Hypoxia-Inducible Factor 1α (HIF1α) that plays a role in cell survival and invasion and telomerase, which is involved in inhibiting cell death by inducing immortality, just to name a few (12).