Researchers who implemented dietary, and or physical activity interventions in overweight and obese adolescents, reported improvements in body composition [11, 14, 15], decrease in systolic blood pressure [16], alanine transaminase (ALT) [17], glucose, insulin, homeostatic model assessment of insulin resistance (HOMA-IR) [18, 19], glycated haemoglobin (HbA1c), total cholesterol, low-density lipoprotein-cholesterol (LDL-C), and triglyceride levels, and an increase in high-density lipoprotein cholesterol (HDL-C) levels [15, 20]. This evidence concerns the gene GPT and Insulin resistance.