High expression (protein or mRNA measurements) has been reported in breast cancer cell lines compared with normal breast cell lines for SPCA2 pumps (Feng et al. 2010), PMCA1/2 pumps (Lee et al. 2002, 2005), ORAI1/3 channels (Faouzi et al. 2011; McAndrew et al. 2011), TRPC3/TRPC6/TRPM8/TRPV6 channels (Aydar et al. 2009; Liu et al. 2014; Peters et al. 2012), P2X4/5/7 channels (Jelassi et al. 2011, 2013), and P2Y2/P2Y6 GPCRs (Jin et al. 2014; Zhang et al. 2017), as well as increased phosphorylation of CAMKII (Chi et al. 2016) and CREB2 (Fan et al. 2012). This evidence concerns the gene ORAI1 and breast cancer.