Of note, when we analyzed the enrichment of the 41 TRAFD1 trans-mediated genes in significantly DEGs in CeD relevant cell types, we found that the enrichment was strongest in IE-CTLs and epithelial cells upon IFN signaling (Supplementary Table 12), suggesting that TRAFD1 and TRAFD1-mediated genes modulate IFN signaling possibly via regulation of NFκB in the context of the CeD inflammatory environment. The gene discussed is NFKB1; the disease is cranioectodermal dysplasia.