In this region, TRAFD1 (which had three lines of evidence in our prioritization analysis described in Gene Prioritization Identifies 118 Likely Causal Celiac Disease Genes) mediated more trans genes (N = 41) than all of the other regional cis-regulators and also had the highest mediation impact (average Z-score difference in effect size between mediated and unmediated analysis = 2.79) (see Methods) (Supplementary Table 7, Supplementary Figures 2B,C). This evidence concerns the gene TRAFD1 and celiac disease.