IFNγ is mainly produced by gsCD4+ T cells and IE-CTLs and is known to disrupt the integrity of the intestinal epithelial cells in CeD-associated villous atrophy (Nilsen et al., 1995; Wapenaar et al., 2004; Abadie et al., 2012). The gene discussed is IFNG; the disease is cranioectodermal dysplasia.