CD274 and neoplasm: PD-L1 staining (Figure 1E) showed that the only one PD-L1-positive tumor (CPS = 2) from the eight samples had the lowest TMEscore but the highest densities of CD8+ T cells and immunosuppressive macrophages M2 inside the tumors (Figure 1F), indicating that the CD8+ T cells inside tumors may be deactivated by PD-L1 signaling and that the TMEscore is a strong indicator of antitumor immunity dynamism.