INS and COVID-19: Moreover, proinflammatory effect (IL-8, MCP-1) of low dose LPS on endothelial cells, high sensitivity of vascular smooth muscle cells to the stimulatory action of LPS, the association of endotoxemia with atherosclerosis, and LPS induced insulin resistance effect are considerable factors which could serve as fertile soil for initiating COVID-19 cytokine storm and microvascular injury in COVID-19 cases (69–71).