CXCL10 and COVID-19: The trigger factor of the cytokine storm may be due to LPS induced CXCL10 expression as discussed above or it may be because of the direct viral effect on the immune system, but the other concept is that low dose LPS can circulate in the plasma in COVID-19 cases with gut dysbiosis and that subclinical endotoxemia can act as a cofactor in facilitating the severe impact of the COVID-19 cytokine storm.