We found that THP-1-differentiated and peripheral blood CD14+ monocyte-derived macrophages, exposed for 72 h to conditioned media from PCa pTA-NK cells, acquire increase the expression of M2-like/TAM genes (CD206, ARG-1, IL10, TGFβ, CXCL8, VEGF), while decreasing the expression of M1-like factors CD81, CD86, IL-12, TNFγ, IFNγ. The gene discussed is CD81; the disease is posterior cortical atrophy.