Secretome analysis revealed that conditioned media of pNK cells isolated PCa-ADK samples are enriched in soluble factors involved in macrophage recruitment and polarization (Supplementary Figure 2, Figure 4A) such as GM-CSF (*p ≤ 0.05), CXCL1/GRO (****p ≤ 0.0001), CXCL11/I-TAC (*p ≤ 0.05), CCL1/I-309 (**p ≤ 0.01), CCL2/MCP-1 (****p ≤ 0.0001), CCL5/RANTES (****p ≤ 0.0001), CCL7/MCP-3 (**p ≤ 0.01), CCL13/MCP-4 (*p ≤ 0.05) and IL-10 (***p ≤ 0.001) (Figure 5A). This evidence concerns the gene CCL5 and posterior cortical atrophy.