The overall secretome analysis (Supplementary Figure 2) revealed signatures characterizing PCa-ADK pTA-NKs involved in inflammation and angiogenesis (CXCL8) (Supplementary Figure 2, Figure 3A), tissue remodelling (MMP-1, MMP-9, uPAR) (Supplementary Figure 2, Figure 3A), monocyte recruitment (CXCL1, CCL2, as the most up-regulated) (Supplementary Figure 2, Figure 4A) and M2-like macrophage polarization (IL-10) (Supplementary Figure 2, Figure 4A). This evidence concerns the gene CCL2 and posterior cortical atrophy.