Using three different PCa cell lines, PC-3, DU-145 and LNCaP, respectively, we observed that their conditioned media were able to induce the CD56brightCD9+CD49a+CXCR4+ phenotype in NK cells derived from healthy controls, together to the capability to produce Angiogenin, Angiopoietin-1, CXCL8, CXCL12. This evidence concerns the gene CXCL12 and posterior cortical atrophy.