PTEN and neoplasm: Neoantigens derived from frameshift mutations represent a type of shared neoantigen that is particularly prominent in clear cell renal cell carcinoma (ccRCC) in which neoantigens from common tumor suppressors such as TP53, PTEN, MLL2, MLL3 and ARID1A have been observed (23) and found to be recognized by tumor-infiltrating lymphocytes (TIL) (24).