PRAME and cancer: However, an important distinction is that some of these are cancer-associated by means of their lineage-specificity, such as MART-1 and CEA, whereas others are cancer germline antigens, such as NY-ESO-1 and PRAME, that are only expressed in immune privileged sites such as the placenta or testis, but are re-expressed due to genomic instability in tumor cells (9).