MAPT and Alzheimer disease: Six out of the nine antibodies (CP13, pS214, T231 in the protein central “proline rich” exon 9 region spanning aa151 to aa243, and the pS396, pS404, pS422 located in the C-terminal tau aa369–aa441 region; see Figure 4A) bound their epitopes in both the normal (monomer) tau in DPSCs and four of them showed their affinity for pathological (aggregated) tau in AD NFTs (Figure 1).