In humans, the DKL1/DIO3 locus at the 14q32 region, contains the paternally expressed genes Delta-like 1 homolog (DLK1), Retrotransposon-like 1 (RTL1), and Iodothyronine deiodinase 3 (DIO3), and the maternally expressed genes MEG3, MEG8, and anti-sense RTL1. MEG3 and MEG8 are long intergenic RNAs; MEG3 has been found dysregulated in several types of tumors, and it is believed to function as a tumor-suppressor gene through interactions with p53 (Zhou et al., 2007). This evidence concerns the gene DIO3 and neoplasm.