CD34 and chronic myelogenous leukemia, BCR-ABL1 positive: Gene expression profiling of the CD34+CD38− fraction (which includes quiescent but mostly non-quiescent LSC) in CML patients revealed a transcriptional profile resembling normal CD34+ myeloid progenitor cells, with decreased levels of transcription factors involved in maintenance of stem-cell fate, suggesting loss of quiescence (Bruns et al., 2009).