Most (>80%) microRNAs dysregulated (GFOLD ≥ |1|) in LSC-enriched and HSC fractions from CML-CP patients had decreased levels compared to primitive (CD34+CD38−/dim) cells from HD, suggesting a global pattern of microRNA downregulation (Figure 1B). The gene discussed is CD38; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.