RAN and chronic myelogenous leukemia, BCR-ABL1 positive: In the work of Zhang et al., they showed, in K562 cells and CML CD34+ cells, that BCR-ABL1 can affect the export of miR-126 precursors from the nucleus to the cytoplasm, through phosphorylation of SPRED1, a negative regulator of RAS superfamily of proteins, interfering with Ran-exportin 5-RCC1 complex (Zhang et al., 2018).