However, inhibition of the NLRP3 inflammasome with intravenous immunoglobulin has been shown to be neuroprotective is an animal model of stroke (Fann et al., 2013), and studies in NLRP3 knockout mice indicate that NLRP3 deletion results in decreased infarct volume, decreased edema and decreased permeability of the blood brain barrier (Yang et al., 2014). This evidence concerns the gene NLRP3 and stroke disorder.