Naveen Shivaved et al. revealed that ascorbic acid, which is abundant in fresh fruits and vegetables, ameliorates oxidative stress and inflammatory response by reducing catalase levels and increasing SOD content, CAT activity, and IL-10 levels in the prefrontal cortex of diabetic rats, indicating the therapeutic potential of ascorbic acid against diabetes comorbid depression (Shivavedi et al., 2019). Here, SOD1 is linked to major depressive disorder.