Pterostilbene, also mentioned in this review, suppresses the activation of TGF-β1/Smad3 and proto-oncogene tyrosine-protein kinase Src/Signal transducer and activator of transcription 3 (Src/STAT3) signaling pathway as to decrease sUA level and alleviate renal fibrosis in hyperuricemic mice (Pan et al., 2019). The gene discussed is SMAD3; the disease is renal fibrosis.