For example, carnosol increases skeletal muscle cell glucose uptake via AMPK-dependent GLUT4 translocation (Vlavcheski et al., 2018), sanggua drink increase GLUT4 gene and protein expressions level in T2DM rats via PI3K/AKT pathway (Cai et al., 2018) and diacylglycerol promotes GLUT4 translocation via activation of PKCε in adipocytes (Tsuchiya et al., 2013). Here, AKT1 is linked to type 2 diabetes mellitus.