FOXP3 and Parkinson disease: Moreover, the treatment of 6-OHDA-induced PD rats with PNU-282987 further increased the number of Foxp3 cells in the SN (44.33 ± 1.67) compared with the 6-OHDA-lesion (24.5 ± 1.61) and the 6-OHDA-lesion + sham groups (20.67 ± 1.28) (One-way ANOVA, F = 69.1, p < 0.001).