A comprehensive analysis of NRP-1 expression in human cancer (consisting of 65 primary breast carcinomas, 95 primary colorectal adenocarcinomas, 90 primary lung carcinomas, and 59 metastases) in 98–100% of all the tumor sections, overexpression of NRP-1 was observed in the tumor-associated vessels [46]. The gene discussed is NRP1; the disease is cancer.