LTBR and infection: To examine the effect of LTβR expression on neutrophils during an acute infection, we analyzed mice after pulmonary infection with Streptococcus pneumoniae, which requires neutrophil activity for clearance.24 The number of colony forming units (CFU) of S. pneumoniae in the lungs of control or LTβRΔN mice was similar, with a trend toward increased CFU (Supplementary Fig. 5f).