We previously identified that LTβR, not HVEM, is the relevant receptor for LIGHT-mediated protection from exacerbated colitis.6,10 LTβR expressing cell types in the colon lamina propria include macrophages, fibroblasts, epithelial cells, and neutrophils.6,10 To identify the disease-relevant LTβR-expressing cell type(s), we crossed mice with a floxed Ltbr allele to Cre mouse lines to delete receptor expression in specific cell lineages. This evidence concerns the gene LTBR and colitis.