A region on chromosome 12, including CD27, TNFRSF1A, and LTBR, is associated with Crohn’s disease risk.57 Recently, a transcriptomic signature of neutrophil activation has been associated with poor outcome in a study of UC patients.58 Our data show that the LIGHT–LTβR signaling network requires cell-type specific fine-tuning to prevent inflammatory disease. This evidence concerns the gene LTBR and Crohn disease.