ALDH2 and cardiomyopathy: Since CYP2E1 and ALDH2 are expressed in the heart, future studies of the opposite regulation of CYP2E1 (i.e., induction) and ALDH2 (i.e., suppression) during the alcohol-mediated production of MDA and/or 4-HNE adducts and the consequent cardiomyopathy would be of interest.