ZRSR2 and posterior cortical atrophy: Based on studies that investigated ZRSR2 structure and binding functions, we hypothesize that ZRSR2’s effect on cell cycle progression in PCa may be mediated by CCND1. Here, we observed that knockdown of ZRSR2 in LNCaP, C4-2, and 22Rv1 cells consistently led to a decrease in CCND1 mRNA and protein expression (Fig. 5a, b).