LEP and hypertensive disorder: Central adiposity accounts for up to 75% of the risk for hypertension, and neurohumoral and renin-angiotensin mediated triggers resulting in impaired pressure natriuresis, physical compression of the kidneys by peri-renal fat (impairing renal blood flow and further increasing renin production), and increased sympathetic activity (via the effect of leptin and melanocortin) have been implicated50.