And although we have recently proposed OGG1 as a potential anti-cancer target, and TH5487 targets a wide range of cancer cells25, DepMap Public Database shows that cancer cell lines derived from bone, such as U2OS, present the lowest OGG1 cancer-dependency scores (DEMETER2; p = 6.3 × 10–6) among lineages. This evidence concerns the gene OGG1 and cancer.