To examine whether CD34+/CD49f+/Itgβ5+ cells are present in native HFs and, if so, what is the niche for these cells, we performed an immunohistochemical analysis for Itgβ5 and a variety of cell surface receptors and ECM proteins that potentially bound to integrins (Fig. 5a). The gene discussed is ITGA6; the disease is Hand-foot syndrome.