We identify 123 loci of which 61 replicate in the 23andMe research cohort, including variants in established drug targets for sleep disorders (HCRTR1, HCRTR2), genes with roles in arousal (TRPC6, PNOC), and genes suggesting an obesity-hypersomnolence pathway (PNOC, PATJ). The gene discussed is PNOC; the disease is obesity due to melanocortin 4 receptor deficiency.