Across many different brain tumor types, SSV-mediated alterations (Fig. 5a) involved RTK pathway-related genes (KRAS, MET, EGFR, NF1), p53/Rb-related genes (CDK4), TERT, MYC family genes (MYC, MYCN, MYB), SWI/SNF complex genes (SMARCB1), and HIPPO pathway-related genes (NF2). Here, CDK4 is linked to brain neoplasm.