CCR5 and Alzheimer disease: The reorganization of actin cytoskeleton and migration of microglia were promoted in response to CCL5 in adult rat microglia and a human microglial cell line.94 Immunohistochemical study demonstrated that CCR3 and CCR5 were present on microglia of normal and AD brains and upregulated in reactive microglia observed in AD.95 Moreover, an increased CCL5 level in microglia in the vicinity of Aβ containing plaques seems to reduce Aβ deposition.96