Damaged neurons increase the expression of endogenous TREM2 ligands, which induces phagocytic activity by microglia.56 In AD brain, TREM2 is detected in neuronal and microglial cells in the vicinity of Aβ-containing plaques that leads to phagocytosis of neuronal cells with Aβ-containing plaques,57 which most possible is sTREM2 attached on neuronal cells. The gene discussed is TREM2; the disease is Alzheimer disease.