The pyroptosis (the expression of NLRP3 and ASC was decreased, Caspase-1 was inactivated, GSDMD-positive rate) in cardiomyocytes of MI/R rats was inhibited and the release of inflammatory factors (IL-1β and IL-18) were alleviated after inhibition of IP3R1. The gene discussed is GSDMD; the disease is myocardial infarction.