Similar results were seen in HCC-364 vr1cells (BRAFWT/BRAF-p61V600E)39 (DC50 of 147 nM, DMAX > 90%) and 293 T-Rex cells overexpressing HA-BRAF-p61V600E (Supplementary Fig. 3a, b). This evidence concerns the gene BRAF and hepatocellular carcinoma.