Instead, in the current study, based on an analysis of mouse fibroblasts, human cancer cells, live tissues from Pten conditional knockout mice, and human invasive breast cancer tissues, we demonstrated that CREB, as a downstream target of the PTEN-AKT1 pathway, transcriptionally upregulates PDGFRα through directly binding to its promoter. This evidence concerns the gene PDGFRA and breast carcinoma.