Similar to U373 cells, manipulation of the activity of AKT1-CREB signaling by ectopic expression of PTEN led to decreased expression of PDGFRα in HGC-27 (a Pten-deficient gastric cancer cell line) cells, and depletion of PDGFRα attenuated the proliferation of HGC-27 cells (Supplementary Fig. S3). This evidence concerns the gene PTEN and gastric cancer.