PLEK and cancer: Protein domain enrichment analysis of AS genes showed inclusion of WD 40 repeat domain, Pleckstrin homology domain, Ubiquitin-interacting motif, Armadillo-type fold, and Zinc finger motifs that are involved in protein targeting/trafficking, cell adhesion, and protein catabolism and signaling suggesting that these domains may perform well-assigned functions in cancer cell growth and signaling (Supplementary Figures 1–4, Data sets 4–7).