As shown in Fig. 3A and S4A, the overexpression of BCAT1 increases LC3B-II expression and suppresses p62 expression in Hela and Huh-7 cells, whereas the knockdown of BCAT1 decreases LC3B-II expression and increases p62 expression in HepG2 cells (Fig. 3B), indicating that BCAT1 induces autophagy in cervical cancer and HCC cells. Here, SQSTM1 is linked to hepatocellular carcinoma.